I (Takumi Kitamura) am a high school student. I happen to find a diary by my classmate Sakura Yamauchi (Minami Hamabe) that reveals she is suffering from a pancreatic disease. I spent time with Sakura, but she dies. 12 years later, due to Sakura’s words, I (Shun Oguri) am now a high school teacher at the same school where I graduated from. While I talk with my student, I remember several months I spent with Sakura. Meanwhile, Kyoko (Keiko Kitagawa), who was Sakura’s friend, is soon to marry. Kyoko also recalls the days she spent with me and Sakura.

Tatsuhiko Shiratori works as a scout, recruiting girls to work in the adult entertainment business. He movies to Yokohama from Shinjuku, Tokyo. He comes into conflict with Masaki Taki who is the CEO of a scout company.

"Girls" follows four beautiful women and depicts the troubles found in their love lives and work place. Yukiko Takigawa (Karina) works at a big advertising firm and has a good looking boyfriend. Seiko Takeda is married and has no children. She works at a large real estate company. Yoko Kosaka is a single woman working at a historic stationary company. Takako Hirai is a single mother who works for a car manufacturer.

During the reign of the eighth shogun of the Tokugawa shogunate, the Yunagaya Domain in the Tohoku region is a small han. But at the han, there is a gold mine. Suddenly, Masaatsu Naito of Yunagaya Domain receives an order to perform Sankin-kotai within 5 days. Sankin-kotai is a custom that requires the daimyo to visit the shogun in Edo. Unfortunately, the time needed to visit the shogun in Edo for Masaatsu Naito is 8 days. Masaatsu Naito also learns he received the order because a high ranking government official wants the gold mine. Also, the expense for Sankin-kotai is high and the Yunagaya Domain is such a small han that it seems impossible to complete. Nevertheless, Masaatsu Naito begins an unexpected operation to complete Sankin-kotai in 5 days.

Tsukasa got into a severe car accident when she was a high school student. She still suffers from the effects of that accident, with memory impairment and needing to use a wheelchair. Tsukasa falls in love with taxi driver Masaki. Even though they have difficulties, they try to make a happy family together, but they encounter another serious situation.